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SRT 2104
$110 – $3,520
Products Details
Product Description
– SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease[1][2][3].
Web ID
– HY-15262
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H24N6O2S2
References
– [1]Hoffmann E, et al. Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.|[2]Jiao D, et al. MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. J Mol Med (Berl). 2018 Sep;96(9):939-949.|[3]Jiang M, et al. Sirtuin 1 activator SRT2104 protects Huntington’s disease mice. Ann Clin Transl Neurol. 2014 Dec;1(12):1047-52.
CAS Number
– 1093403-33-8
Molecular Weight
– 516.64
Compound Purity
– 99.10
SMILES
– O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4
Clinical Information
– Phase 2
Research Area
– Metabolic Disease; Neurological Disease; Cancer
Solubility
– DMSO : 5 mg/mL (ultrasonic)
Target
– Sirtuin
Isoform
– SIRT1
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
