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SJ-C1044

SKU T200357-25 mg Category Small Compound Brand: TargetMol

Price range: 2,640 CAD through 4,416 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

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Products Details

Product Description

– SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T200357

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H14F7N7O

CAS Number

– 2121503-76-0

Molecular Weight

– C25H14F7N7O

SMILES

– O=C(NC1=CC(=CC=C1F)NC2=NC=CC=C2C=3N=CN=C4N=CNC43)C=5C=C(C=C(C5)C(F)(F)F)C(F)(F)F

Target

– Others

Pathway

– Tyrosine Kinase/Adaptors|||Angiogenesis|||MAPK|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.