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S18-000003
$260 – $2,100
Products Details
Product Description
– S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations[1][2].
Web ID
– HY-119366
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H25F3N2O4S
References
– [1]Sasaki Y, et, al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.|[2]Imura C, et, al. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. J Dermatol Sci. 2019 Mar;93(3):176-185.
CAS Number
– 2068119-11-7
Molecular Weight
– 518.55
Compound Purity
– 99.31
SMILES
– FC1=C(NC(C(C)(C)C2=CC=C(NC(CC3=CC=C(S(CC)(=O)=O)C=C3)=O)C=C2F)=O)C=CC(F)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– ROR
Isoform
– RORγ
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
