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PKM2-IN-1

SKU T4170-1 mg Category Small Compound Brand: TargetMol

Price range: 54 CAD through 2,048 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

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Products Details

Product Description

– PKM2-IN-1 (compound 3k) exhibits inhibitory activity against PKM2 with an IC50 of 2.95 μM, while the IC50 for PKM1 is 4-5 times higher.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4170

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H19NO2S2

Citations

– 1. Deng H, Qian X, Zhang Y, et al.Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis.Digestive Diseases and Sciences.2024: 1-15.

References

– Ning X, et al. Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. Eur J Med Chem. 2017 Sep 29;138:343-352.

CAS Number

– 94164-88-2

Molecular Weight

– C18H19NO2S2

Compound Purity

– 0.9949

SMILES

– CC1=C(CSC(=S)N2CCCCC2)C(=O)c2ccccc2C1=O

Pathway

– Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.