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P 22077

SKU T2424-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 51 CAD through 762 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2424

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C12H7F2NO3S2

Citations

– 1. Chen F, Zhang W, Xie D, et al. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters. Nucleic Acids Research. 2020, 48(18): 10211-10225 2. Wu W, Xu H, Liao C, et al. Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology. 2022: 1-15 3. Yue X, Liu T, Wang X, et al.Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.Acta Pharmaceutica Sinica B.2023

References

– Tian X, et al. Assay Drug Dev Technol, 2011, 9(2), 165-173.

CAS Number

– 1247819-59-5

Molecular Weight

– C12H7F2NO3S2

Compound Purity

– 0.9842

SMILES

– CC(=O)c1cc(c(Sc2ccc(F)cc2F)s1)[N+]([O-])=O

Pathway

– Cell Cycle/Checkpoint|||Ubiquitination|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.