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LY-411575

SKU T6063-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 61 CAD through 1,022 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6063

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H23F2N3O4

Citations

– 1. Yang D L, Zhang Y, He L, et al. Demethylzeylasteral (T-96) Initiates Extrinsic Apoptosis Against Prostate Cancer cells by Inducing ROS-Mediated ER Stress and Suppressing Autophagic Flux. Biological Research. 2021, 54(1): 1-14. 2. Zhang S, Lou H, Lu H, et al.Characterization of Proliferation Medium and Its Effect on Differentiation of Muscle Satellite Cells from Larimichthys crocea in Cultured Fish Meat Production.Fishes.2023, 8(9): 429. 3. Xin Q, Niu R, Chen Q, et al.Stable cytoactivity of piscine satellite cells in rice bran-gelatin hydrogel scaffold of cultured meat.International Journal of Biological Macromolecules.2024: 134242. 4. Lou H, Lu H, Zhang S, et al.Highly aligned myotubes formation of piscine satellite cells in 3D fibrin hydrogels of cultured meat.International Journal of Biological Macromolecules.2024: 136879.

References

– Wong GT, et al, J Biol Chem, 2004, 279(13), 12876-12882.

CAS Number

– 209984-57-6

Molecular Weight

– C26H23F2N3O4

Compound Purity

– 0.9805

SMILES

– C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O

Pathway

– Stem Cells|||Neuroscience|||Apoptosis|||Proteases/Proteasome

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.