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Kobe0065

SKU T1876-5 mg Category Small Compound Brand: TargetMol

Price range: 62 CAD through 1,034 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Kobe0065 is a novel and effective small-molecule compound that inhibits the Ras-Raf interaction by structure-based drug design (SBDD); it displays potent activity, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1876

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H11ClF3N5O4S

Citations

– 1. Wang J, Yao N, Hu Y, et al. PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras. Cellular and Molecular Life Sciences. 2022 Sep 15;79(10):520.

References

– Shima F, et al. Proc Natl Acad Sci U S A. 2013, 110(20):8182-7.

CAS Number

– 436133-68-5

Molecular Weight

– C15H11ClF3N5O4S

Compound Purity

– 0.9958

SMILES

– Cc1ccc(NC(=S)NNc2c(cc(cc2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)cc1Cl

Target

– Others

Pathway

– GPCR/G Protein|||Apoptosis|||MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.