GRK2-IN-1 hydrochloride (2055990-90-2 free base)

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GRK2-IN-1 hydrochloride (2055990-90-2 free base)

SKU T13714L-25 mg Category Small Compound Brand: TargetMol

Price range: 3,872 CAD through 6,880 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

100 mg 25 mg 50 mg

Clear

Products Details

Product Description

– GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T13714L

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H26ClFN4O4

References

– Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.

Molecular Weight

– C24H26ClFN4O4

SMILES

– FC1=C(C(NCC2=NNC=C2)=O)C=C([C@H]3[C@H](COC4=CC=C(OCO5)C5=C4)CNCC3)C=C1.[H]Cl

Target

– Aminopeptidase|||Topoisomerase|||Mitophagy|||HIV Protease|||Autophagy|||Apoptosis|||NF-κB|||Endogenous Metabolite

Pathway

– GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.