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GIBH-130

$110$950

Products Details

Product Description

– GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the IL-1β secretion by activated microglia (IC50=3.4 nM).

Web ID

– HY-101860

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neurodegeneration

Molecular Formula

– C20H20N6O

References

– [1]Zhou W, et al. Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer’s Disease Models. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.

CAS Number

– 1252608-59-5

Molecular Weight

– 360.41

Compound Purity

– 99.87

SMILES

– O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– DMSO : 50 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)

Target

– Interleukin Related

Isoform

– IL-1

Pathway

– Immunology/Inflammation

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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