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Ditolylguanidine
$50 – $60
Products Details
Product Description
– Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer[1][2][3][4].
Web ID
– HY-14218
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H17N3
References
– [1]Shimizu I, et al. Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. Br J Pharmacol. 2000 Oct;131(3):610-6.|[2]John CS, et al. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sci. 1995;56(26):2385-92.|[3]Moody TW, et al. Sigma ligands inhibit the growth of small cell lung cancer cells. Life Sci. 2000 Apr 7;66(20):1979-86.|[4]Moison D, et al. Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology. 2003 Dec;45(7):945-53.
CAS Number
– 97-39-2
Molecular Weight
– 239.32
Compound Purity
– 99.03
SMILES
– CC1=C(NC(NC2=CC=CC=C2C)=N)C=CC=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 150 mg/mL (ultrasonic)
Target
– Sigma Receptor
Isoform
– Sigma 1 Receptor;Sigma 2 Receptor
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
