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Conglobatin
SKU
HY-119906-2500μg
Category Natural Products
Tags Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease, Apoptosis;HSP, Cancer
$2,150
Only 1000 item(s) left in stock.
Products Details
Product Description
– Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo[1][2][3].
Web ID
– HY-119906
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H38N2O6
References
– [1]Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7.|[2]Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14;13:150.|[3]Li LY, et, al. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. 2015 Jun 30;6(18):15940-52.
CAS Number
– 72263-05-9
Molecular Weight
– 498.61
SMILES
– C[C@@H](C[C@H](/C=C(C(O[C@H]1CC2=CN=CO2)=O)C)C)[C@@H](OC(/C(C)=C/[C@@H](C[C@@H]1C)C)=O)CC3=CN=CO3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HSP
Isoform
– HSP90
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Natural Products
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