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CCCP

SKU T7081-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 66 CAD through 155 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)100 mg 200 mg 500 mg

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Products Details

Product Description

– CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T7081

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C9H5ClN4

Citations

– 1. Xu Q, Fu Q, Li Z, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nature Metabolism. 2021: 1-21. 2. Fan Y, Li C, Bai S, et al. NIR‐II Emissive Ru (II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy. Small. 2022: 2201625 3. Zhang Y, Xu X, Hu M, et al. SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death & Differentiation. 2020: 1-15. 4. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021 Oct;17(10):3221-3237. 5. Liu C, Wang L, Wang P, et al.The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis.International Journal of Molecular Sciences.2023, 24(10): 8652. 6. Wang K, Zhou Z, Huang L, et al.PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2024, 1870(2): 166919. 7. Liu C, Liu J, Lu Q, et al.The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline.International Journal of Molecular Sciences.2024, 25(3): 1819. 8. Malla S, Nyinawabera A, Neupane R, et al.Novel Thienopyrimidine-Hydrazinyl Compounds Induce DRP1-Mediated Non-Apoptotic Cell Death in Triple-Negative Breast Cancer Cells.Cancers.2024, 16(15): 2621. 9. Hu K, Lai Y, Zhou J, et al.Aberrant activation of adenine nucleotide translocase 3 promotes progression and chemoresistance in multiple myeloma dependent on PINK1 transport.International Journal of Biological Sciences.2025, 21(1): 233.

References

– Padman BS, et al. The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells. Autophagy. 2013 Nov 1;9(11):1862-75.

CAS Number

– 555-60-2

Molecular Weight

– C9H5ClN4

Compound Purity

– 0.9855

SMILES

– ClC1=CC=CC(NN=C(/C#N)C#N)=C1

Pathway

– Apoptosis|||Microbiology/Virology|||NF-κB|||Metabolism|||Immunology/Inflammation|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.