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Bobcat339
$60 – $320
Products Details
Product Description
– Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
Web ID
– HY-111558
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H12ClN3O
Citations
– Aquaculture. 2023: 739234.|Brain Sci. 2023 Apr 10, 13(4), 644.|Research Square Print. 2023 Mar 14.|Research Square Print. November 29th, 2022.|Bioelectrochemistry. 2023 Apr 4;152:108433.|Cancers (Basel). 2022 Jun 16;14(12):2983.|Clin Sci. 2023 Aug 31;137(16):1265-1283.|Environ Sci Technol. 2021 Feb 11.|J Clin Invest. 2023 Aug 29;e170173.|J Pharm Biomed Anal. 2021 Jun 24;203:114228.|Mol Pain. 2022 Apr;18:17448069221143671.|Neuropharmacology. 2023 Nov 24:109799.|Theranostics. 2021 Jun 11;11(16):7640-7657.
References
– [1]Chua GNL, et, al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31; 10(2): 180-185.
CAS Number
– 2280037-51-4
Molecular Weight
– 297.74
Compound Purity
– 99.73
SMILES
– NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA Methyltransferase;TET Protein
Isoform
– TET1;TET2
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
