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Bafetinib

SKU T6311-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 50 CAD through 766 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6311

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H31F3N8O

Citations

– 1. Jing Y, Dai X, Yang L, et al. STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020, 6(17): eaax9455. 2. Wu J, Nie Y, Wang J, et al. Fcγ receptor‐mediated phagocytosis pathway was involved in phagocytosis of mIgM+ B lymphocytes from largemouth bass (Micropterus salmoides). Journal of Fish Biology. 2022 3. Weng H, Xiong K P, Wang W, et al.Aspartoacylase suppresses prostate cancer progression by blocking LYN activation.Military Medical Research.2023, 10(1): 1-25.

References

– Kimura S, et al. Blood. 2005, 106(12), 3948-3954.

CAS Number

– 859212-16-1

Molecular Weight

– C30H31F3N8O

Compound Purity

– 0.9968

SMILES

– CN(C)[C@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1

Pathway

– Tyrosine Kinase/Adaptors|||Autophagy|||Cytoskeletal Signaling|||Angiogenesis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.