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Products Details
Product Description
– Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition[1].
Web ID
– HY-144636
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H30O3
References
– [1]Kudo Y, Endo S, Fujita M, et al. Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2022;65(6):4878-4892.
CAS Number
– 2765008-88-4
Molecular Weight
– 330.46
SMILES
– O=C(C1=CC=C(C=C1)CCCCCCCCCCC)/C=C/C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Atg4;Autophagy;Cathepsin;Phospholipase
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
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