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Products Details
Product Description
– Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].
Web ID
– HY-106443
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C14H20ClN3O3
References
– [1]Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.|[2]Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.
CAS Number
– 289893-25-0
Molecular Weight
– 313.78
SMILES
– Cl/C(C1=C[N+]([O-])=CC=C1)=NOC[C@H](O)CN2CCCCC2
Clinical Information
– Phase 3
Research Area
– Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– HSP
Isoform
– HSP
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
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