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Products Details
Product Description
– Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice[1].
Web ID
– HY-146435
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H16O6
References
– [1]Roh K, et al. Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema. Eur J Med Chem. 2020;197:112280.
CAS Number
– 2721484-76-8
Molecular Weight
– 376.36
SMILES
– O=C(C1=C(C=C(C=C1)O)OC(C2=CC=CC=C2)=O)/C=C/C3=CC=C(C(O)=C3)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– TNF Receptor
Isoform
– CD40
Pathway
– Apoptosis
Product type
– Reference compound
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