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AM-6761

SKU T26610-25 mg Category Small Compound Brand: TargetMol

Price range: 4,832 CAD through 8,800 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

100 mg 25 mg 50 mg

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Products Details

Product Description

– AM-6761 is a potent inhibitor of the MDM2-p53 interaction. In the SJSA-1 osteosarcoma xenograft model, AM-6761 shows excellent antitumor activity with an ED50 of 11 mg/kg.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T26610

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C33H37Cl2FN2O5S2

References

– Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Sun D, Medina JC. Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres. J Med Chem. 2014 Apr 10;57(7):2963-88. doi: 10.1021/jm401911v. Epub 2014 Mar 27. PubMed PMID: 24601644.

CAS Number

– 1584732-36-4

Molecular Weight

– C33H37Cl2FN2O5S2

SMILES

– [C@H](CS(C(C)(C)C)(=O)=O)(N1[C@@H]([C@H](C[C@@](CC=2SC(CC(O)=O)=CN2)(C)C1=O)C3=CC(Cl)=CC=C3)C4=CC(F)=C(Cl)C=C4)[C@@H]5CC5

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.