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Navitoclax

SKU T2101-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 62 CAD through 515 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Navitoclax (ABT-263) is a potent oral Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM), demonstrating antitumor activity and inducing apoptosis.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2101

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C47H55ClF3N5O6S3

Citations

– 1. Wang S, Wang Z, Wang X, et al. Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents. Acta Pharmacologica Sinica. 2022: 1-11. 2. Torres P, Anerillas C, Ramírez-Núñez O, et al. The motor neuron disease mouse model hSOD1-G93A shows a non-canonical profile of senescence biomarkers. Disease Models & Mechanisms. 2022 3. Torres P, Anerillas C, Ramírez-Núñez O, et al. A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers. Disease models & mechanisms. 2022, 15(8): dmm049059. 4. Bhatt H N, Diwan R, Borrego E A, et al.A photothermal driven chemotherapy for the treatment of metastatic melanoma.Journal of Controlled Release.2023, 361: 314-333. 5. Bhatt H N, Diwan R, Estevao I L, et al.Cadherin-11 targeted cell-specific liposomes enabled skin fibrosis treatment by inducing apoptosis.Journal of Controlled Release.2024, 370: 110-123. 6. Seiboldt T, Zeiser C, Nguyen D, et al.Synergy of retinoic acid and BH3 mimetics in MYC (N)-driven embryonal nervous system tumours.British Journal of Cancer.2024: 1-15.

References

– Tse C, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008 May 1;68(9):3421-8.

CAS Number

– 923564-51-6

Molecular Weight

– C47H55ClF3N5O6S3

Compound Purity

– 0.9888

SMILES

– C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.