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Adavosertib

SKU T2077-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 64 CAD through 462 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2077

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H32N8O2

Citations

– 1. Al‐Jamaei A A H, de Visscher J G A M, Ramadugula V S, et al. WEE1 kinase inhibitor MK‐1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status. Oral Diseases. 2022 2. Gao X, Ren X, Wang F, et al.Immunotherapy and drug sensitivity predictive roles of a novel prognostic model in hepatocellular carcinoma.Scientific Reports.2024, 14(1): 9509. 3. Esposito E, Marra G, Catalano R, et al.Therapeutic potential of targeting the FLNA‐regulated Wee1 kinase in adrenocortical carcinomas.International Journal of Cancer.2024

References

– Hirai H, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther. 2009 Nov;8(11):2992-3000.

CAS Number

– 955365-80-7

Molecular Weight

– C27H32N8O2

Compound Purity

– 0.9986

SMILES

– C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C(C(C)(C)O)C=CC5

Target

– Others

Pathway

– Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.