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LY-364947

SKU T2048-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 94 CAD through 1,477 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2048

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H12N4

Citations

– 1. Han L, Song B, Zhang P, et al.PC3T: a signature-driven predictor of chemical compounds for cellular transition.Communications Biology.2023, 6(1): 989. 2. Liu S, Yan X, Guo J, et al.Periodontal ligament‐associated protein‐1 knockout mice regulate the differentiation of osteoclasts and osteoblasts through TGF‐β1/Smad signaling pathway.Journal of Cellular Physiology.2023 3. Liu S, Yu X, Guo Q, et al.Periodontal ligament‐associated protein‐1 promotes osteoclastogenesis in mice by modulating TGF‐β1/Smad1 pathway.Journal of Periodontology.2023 4. Liu F, Zhao H, Kong R, et al. Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis. Journal of Genetics and Genomics. 2021 5. Li Q, Ma Y, Liu X L, et al. Anti-proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF-β1/p53 signaling pathway. Oncology Reports. 2020, 44(5): 2093-2107 6. Deng Y, Li L, Zhu J H, et al. COX-2 promotes the osteogenic potential of BMP9 through TGF-β1/p38 signaling in mesenchymal stem cells. Aging (Albany NY). 2021, 13(8): 11336. 7. Li Q, Ma Y, Liu X L, et al. Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway. Oncology Reports. 2020 Nov;44(5):2093-2107

References

– Li HY, et al. J Med Chem, 2006, 49(6), 2138-2142.

CAS Number

– 396129-53-6

Molecular Weight

– C17H12N4

Compound Purity

– 0.9965

SMILES

– N1C=C(C(=N1)C1=NC=CC=C1)C1=CC=NC2=CC=CC=C12

Target

– Others

Pathway

– Apoptosis|||NF-κB|||MAPK|||Metabolism|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.