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MRTX1133

SKU T9303-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 315 CAD through 3,936 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T9303

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C33H31F3N6O2

Citations

– 1. Bian Y, Shan G, Bi G, et al.Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis.Redox Biology.2024: 103361.

References

– Wang X, et al. Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor. J Med Chem. 2022 Feb 24;65(4):3123-3133.

CAS Number

– 2621928-55-8

Molecular Weight

– C33H31F3N6O2

Compound Purity

– 0.996

SMILES

– Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2C[C@@H]3CC[C@H](C2)N3)c2c(C#C)c(F)ccc2c1

Pathway

– MAPK|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.