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Pevonedistat

SKU T6332-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 77 CAD through 1,208 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM) with therapeutic potential for myelodysplastic syndromes (MDS) and antitumor activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6332

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H25N5O4S

Citations

– 1. Qin Z, Hu H, Sun W, et al. miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells. Cancers. 2021 Feb 4;13(4):618. doi: 10.3390/cancers13040618. 2. Hussain M, Lu Y, Tariq M, et al. A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism. Iscience. 2022, 25(7): 104591. 3. Chen S M, Lin T K, Tseng Y Y, et al. Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21. Cancer Medicine. 2018 Aug;7(8):3988-4003 4. Fu Z, Liao W, Ma H, et al. Inhibition of neddylation plays protective role in lipopolysaccharide-induced kidney damage through CRL-mediated NF-κB pathways. Am J Transl Res. 2019, 11(5): 2830-2842 5. Sun Y, Baechler S A, Zhang X, et al.Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex.Nature Communications.2023, 14(1): 3762. 6. Zhong C, Zhu R, Jiang T, et al.Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple‐Negative Breast Cancer.Advanced Science.2023: 2305035. 7. Zhao X, Zhong C, Zhu R, et al.Structure–Activity Relationship Studies of Substituted 2-Phenyl-1, 2, 4-triazine-3, 5 (2 H, 4 H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.Journal of Medicinal Chemistry.2024 8. Li P, Hu X, Fan Z, et al.Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.Journal of Hematology & Oncology.2024, 17(1): 77. 9. Ying S, Chi H, Wu X, et al.Selective and Orally Bioavailable c-Met PROTACs for the Treatment of c-Met-Addicted Cancer.Journal of Medicinal Chemistry.2024 10. Dai Y, Li H, Fan S, et al.Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma.Cell Death & Disease.2025, 16(1): 1-12.

References

– Foster JH, et al. The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma. Int J Mol Sci. 2021 Jun 18;22(12):6565.

CAS Number

– 905579-51-3

Molecular Weight

– C21H25N5O4S

Compound Purity

– 0.9963

SMILES

– NS(=O)(=O)OC[C@@H]1CC(C[C@@H]1O)n1ccc2c(NC3CCc4ccccc34)ncnc12

Pathway

– Ubiquitination|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.