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Irinotecan

SKU T6228-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 46 CAD through 366 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6228

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C33H38N4O6

Citations

– 1. Larson T S, Glish G L, Lockett M R. Spatially resolved quantification of drug metabolism and efficacy in 3D paper-based tumor mimics. Analytica Chimica Acta. 2021: 339091. 2. Zhu A, Ji Z, Zhao J, et al. Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans. Phytomedicine. 2019: 153102 3. Zhang T, Tian E, Xiong Y, et al.Development of a RNA-protein complex based smart drug delivery system for 9-hydroxycamptothecin.International Journal of Biological Macromolecules.2024: 133871.

References

– Keyvani-Ghamsari S, et al. Effect of irinotecan on HMGB1, MMP9 expression, cell cycle, and cell growth in breast cancer (MCF-7) cells. Tumour Biol. 2017 Apr;39(4):1010428317698354.

CAS Number

– 97682-44-5

Molecular Weight

– C33H38N4O6

Compound Purity

– 0.9989

SMILES

– CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12

Pathway

– DNA Damage/DNA Repair|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.