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Saclofen

SKU T4440-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 82 CAD through 1,530 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4440

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C9H12ClNO3S

Citations

– 1. Wang Y J, Zan G Y, Xu C, et al.The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.Nature Communications.2023, 14(1): 7903.

References

– Drew C A, Johnston G A R, Kerr D I B, et al. Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists[J]. Neuroscience letters, 1990, 113(1): 107-110.

CAS Number

– 125464-42-8

Molecular Weight

– C9H12ClNO3S

Compound Purity

– 0.9954

SMILES

– NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

Pathway

– Membrane transporter/Ion channel|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.