ML385

SKU T4360-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 75 CAD through 1,515 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Products Details

Product Description

– ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.
For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4360

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H25N3O4S

Citations

– 1. Jiang H, Lin C, Cai T, et al.Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head.Phytotherapy Research.2023 2. Tao M, Yan W, Chen C, et al.Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.Life Sciences.2023: 121847. 3. Jin B, Chen Y, Wang J, et al.Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress.Journal of Cellular and Molecular Medicine.2023 4. Zhang L, Hu C, Jin B, et al.Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.Cardiovascular Drugs and Therapy.2023: 1-14. 5. Lan J, Zhou Y, Wang H, et al.Protective Effect of Human Umbilical Cord Mesenchymal Stem Cell Derived Conditioned Medium in a Mutant TDP-43 Induced Motoneuron-Like Cellular Model of ALS.Brain Research Bulletin.2022 6. Fan P, Lu Y, Wei H, et al.Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.Metabolic Brain Disease.2023: 1-17. 7. Zheng W, Yang H, Lin H, et al.ML385 suppresses the proliferation, migration, and invasion of thyroid carcinoma cells by impairing aerobic glycolysis.Molecular & Cellular Toxicology.2023: 1-10. 8. Chen F, Zhu J, Wang W. Ulinastatin Attenuates LPS-Induced Inflammation and Inhibits Endoplasmic Reticulum Stress–Induced Apoptosis in Renal Tubular Epithelial Cells via Regulation of the TLR4/NF-κB and Nrf2/HO-1 Pathways. Inflammation. 2021: 1-10. 9. Liu Y, Hou M, Pan Z, et al. Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression. Journal of Nanobiotechnology. 2022, 20(1): 1-20 10. Wu Y, Zeng S, Wan B, et al. Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis. International Immunopharmacology. 2021, 90: 107187

References

– Singh A, et al. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS Chem Biol. 2016 Nov 18;11(11):3214-3225.

CAS Number

– 846557-71-9

Molecular Weight

– C29H25N3O4S

Compound Purity

– 0.9998

SMILES

– Cc1sc(NC(=O)Cc2ccc3OCOc3c2)nc1-c1ccc2N(CCc2c1)C(=O)c1ccccc1C

Pathway

– Apoptosis|||Immunology/Inflammation

Product type

– Small Compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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For Research Use Only. All Immunomart products are sold strictly for laboratory research use only (RUO). Not for human or veterinary consumption, therapeutic, or diagnostic use.