12(S)-HETrE
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12(S)-HETrE

SKU T36773-25 μg Category Brand:

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Products Details

Product Description

– 12(S)-HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.

Web ID

– T36773

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H34O3

CAS Number

– 72710-10-2

Molecular Weight

– C20H34O3

SMILES

– C([C@H](C/C=CCCCCC)O)=C/C=CCCCCCCC(O)=O

Pathway

– Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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