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AKB-6899

SKU T29797-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 109 CAD through 1,563 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T29797

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H11FN2O4

References

– Roda JM, Wang Y, Sumner LA, Phillips GS, Marsh CB, Eubank TD. Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189(6):3168-77. doi: 10.4049/jimmunol.1103817. Epub 2012 Aug 6. PubMed PMID: 22869907; PubMed Central PMCID: PMC3436995.

CAS Number

– 1007377-55-0

Molecular Weight

– C14H11FN2O4

Compound Purity

– 0.9711

SMILES

– OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1

Pathway

– Angiogenesis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.