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IPSU
$168 – $816
Products Details
Product Description
– IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
Web ID
– HY-13796
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H27N5O2
References
– [1]Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleeparchitecture for the treatment of insomnia. J Med Chem. 2013 Oct 10;56(19):7590-607.|[2]Callander GE, et al. Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors. Front Neurosci. 2013 Dec 3;7:230.|[3]Hoyer D, et al. Distinct effects of IPSU and suvorexant on mouse sleep architecture.
CAS Number
– 1373765-19-5
Molecular Weight
– 405.49
Compound Purity
– 98.10
SMILES
– COC1=CC=NC(N(CC2)CCC2(C3=O)CCCN3CC4=CNC5=CC=CC=C54)=N1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : ≥ 30 mg/mL
Target
– Orexin Receptor (OX Receptor)
Isoform
– OX2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
