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VBIT-4

SKU T13287-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 149 CAD through 2,752 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T13287

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H23ClF3N3O3

Citations

– 1. Zheng W, Zhou Z, Rui Y, et al.TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.Signal Transduction and Targeted Therapy.2023, 8(1): 79. 2. He B, Yu H, Liu S, et al.Mitochondrial cristae architecture protects against mtDNA release and inflammation.Cell Reports.2022, 41(10): 111774. 3. Zhang Z, Zhou H, Gu W, et al.CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes.Nature Chemical Biology.2024: 1-11. 4. Tong Z, Zou J P, Wang S Y, et al.Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense.Advanced Science.2024: 2308890. 5. Zhu Z, Cao Y, Jian Y, et al.CerS6 links ceramide metabolism to innate immune responses in diabetic kidney disease.Nature Communications.2025, 16(1): 1528.

References

– Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

CAS Number

– 2086257-77-2

Molecular Weight

– C21H23ClF3N3O3

Compound Purity

– 0.9993

SMILES

– C(CC(NC1=CC=C(Cl)C=C1)=O)(CO)N2CCN(CC2)C3=CC=C(OC(F)(F)F)C=C3

Target

– Others

Pathway

– Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.