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Products Details
Product Description
– INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity[1].
Web ID
– HY-12636
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H27N3O5
References
– [1]Bin-Bing S Zhou, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul;10(1):39-50.
CAS Number
– 791826-72-7
Molecular Weight
– 413.47
SMILES
– O=C(N([C@H](C(N1CC=C(C2=CC=CC=C2)CC1)=O)[C@@H](C(NO)=O)C3)CC43CC4)OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MMP
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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