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Fluoxetine

SKU T0450-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 341 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T0450

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H18F3NO

Citations

– 1. Jiang B, Wang H, Wang J L, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biological Psychiatry. 2019, 85(8): 650-666 2. Persaud R, Li S C, Chao J D, et al. Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1. Cell Chemical Biology. 2021 3. Wu X, Lv J, Zhang S, et al. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacologica Sinica. 2021: 1-9. 4. Lv J, Liang Y, Zhang S, et al. DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels. ACS Chemical Neuroscience. 2019, 10(6): 2786-2793 5. Liu Y, Tang W, Ji C, et al. The selective SIK2 inhibitor ARN-3236 produces strong antidepressant-like efficacy in mice via the hippocampal CRTC1-CREB-BDNF pathway. Frontiers in pharmacology. 2020, 11. 6. Liu L, Ji C H, Wang Y, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behavioural Brain Research. 2020: 113038. 7. Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience Letters. 2021 Jan 18;742:135535. doi: 10.1016 8. Zhang H, Xu H, Tang Q, et al. The selective serotonin reuptake inhibitors enhance the cytotoxicity of sorafenib in hepatocellular carcinoma cells. Anti-Cancer Drugs. 2021, 32(8): 793-801. 9. Ge J B, Jiang B, Shi T S, et al.Cucurbitacin B exerts significant antidepressant-like effects in a chronic unpredictable mild stress model of depression: Involvement of the hippocampal BDNF-TrkB system.International Journal of Neuropsychopharmacology.2023: pyad052.

References

– Hwang S, et al. Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells. Chonnam Med J. 2020 Jan;56(1):20-26.

CAS Number

– 54910-89-3

Molecular Weight

– C17H18F3NO

Compound Purity

– 0.9965

SMILES

– CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1

Target

– Aromatase

Pathway

– Immunology/Inflammation|||GPCR/G Protein|||Autophagy|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.