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WP1066
Price range: 70 CAD through 504 CAD
Products Details
Product Description
– WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
Web ID
– T2156
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H14BrN3O
Citations
– 1. Li M, Yu H. Identification of WP1066, an inhibitor of JAK2 and STAT3, as a Kv1. 3 potassium channel blocker. British Journal of Pharmacology. 2021 Jul;178(13):2617-2631. doi: 10.1111/bph.15441. Epub 2021 May 20.
2. Ma X, Xu W, Jin X, et al.Telocinobufagin inhibits osteosarcoma growth and metastasis by inhibiting the JAK2/STAT3 signaling pathway.European Journal of Pharmacology.2023: 175529.
3. Hu Z, Sui Q, Jin X, et al.IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma.Journal of Experimental & Clinical Cancer Research.2024, 43(1): 63.
References
– Verstovsek S, et al. Clin Cancer Res, 2008, (3), 788-796.
CAS Number
– 857064-38-1
Molecular Weight
– C17H14BrN3O
Compound Purity
– 0.9892
SMILES
– C[C@H](NC(=O)C(=Cc1cccc(Br)n1)C#N)c1ccccc1
Pathway
– Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Apoptosis|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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