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Veliparib

SKU T2591-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 83 CAD through 1,435 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2591

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H16N4O

Citations

– 1. Kanmin Mao,Jialong Chen,Honglin Yu,Huihui Li,Yixian Ren. Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson’s disease. Aging Cell. 2020 Jun;19(6):e13163 2. Epub 2020 May 31 PARP1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via TFEB-dependent autophagy in mutant α-synucleinA53T model of Parkinson’s disease. aging cell. 2020 Jun;19(6):e13163 3. Wang J, Xing W, Lin Y, et al. Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma. Journal of Clinical Laboratory Analysis. 2022: e24435 4. Liu C, Li J, Xu F, et al.PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer.Molecular Cancer.2024, 23(1): 111.

References

– Donawho CK, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37.

CAS Number

– 912444-00-9

Molecular Weight

– C13H16N4O

Compound Purity

– 0.9866

SMILES

– C(N)(=O)C1=C2C(N=C(N2)[C@@]3(C)CCCN3)=CC=C1

Pathway

– Autophagy|||DNA Damage/DNA Repair|||Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.