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Tranilast

SKU T2690-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 58 CAD through 501 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2690

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H17NO5

Citations

– 1. Huang W, Zhang L, Yang M, et al. Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway. Journal of Experimental & Clinical Cancer Research. 2021, 40(1): 1-14 2. Huang W, Zhang L, Yang M, et al. Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway. Journal of Experimental & Clinical Cancer Research. 2021, 40(1): 1-14 3. Huang R, Li S, Tian C, et al. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathway of PI3K/Akt/mTOR in esophageal squamous cell carcinoma. british journal of cancer. 2022 Nov;127(8):1424-1439. 4. Huang R, Li S, Tian C, et al. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. British Journal of Cancer. 2022: 1-16. 5. Liu J, Zhao Z, Wen J, et al. TNF-α differently regulates TRPV2 and TRPV4 channels in human dental pulp cells. International endodontic journal. 2019 6. Huang R, Wang F, Yang Y, et al. Recurrent activations of transient receptor potential vanilloid‐1 and vanilloid‐4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells. FEBS Open Bio. 2019 Jan 18;9(2):206-225 7. Amissah O B, Chen W, de Dieu Habimana J, et al.NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route.Cancer Cell International.2024, 24(1): 1-18. 8. Qin W, Ding Y, Zhang W, et al.Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.Journal of Lipid Research.2025: 100740.

References

– Suzawa H, et al. Jpn J Pharmacol, 1992, 60(2), 91-96.

CAS Number

– 53902-12-8

Molecular Weight

– C18H17NO5

Compound Purity

– 0.999

SMILES

– N(C(C=CC1=CC(OC)=C(OC)C=C1)=O)C2=C(C(O)=O)C=CC=C2

Pathway

– Immunology/Inflammation|||GPCR/G Protein|||Endocrinology/Hormones

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.