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Topovale

SKU T9088-1 mg Category Small Compound Brand: TargetMol

Price range: 141 CAD through 1,539 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T9088

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H23N3O5

References

– Zhou W, Dai Z, Chen Y, Wang H, Yuan Z. High-Dimensional descriptor selection and computational QSAR modeling for antitumor activity of ARC-111 analogues Based on Support Vector Regression (SVR). Int J Mol Sci. 2012;13(1):1161-72. doi: 10.3390/ijms13011161. PubMed PMID: 22312310; PubMed Central PMCID: PMC3269744.

CAS Number

– 500214-53-9

Molecular Weight

– C23H23N3O5

Compound Purity

– 0.9994

SMILES

– C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5

Pathway

– DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.