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Tofacitinib

SKU T6321-5 mg Category Small Compound Brand: TargetMol

Price range: 48 CAD through 440 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Tofacitinib (Tasocitinib) is a Janus kinase inhibitor that inhibits JAK3/2/1 (IC50=1/20/112 nM) and is orally active. Tofacitinib is used for the [research relevance to related conditions].

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6321

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H20N6O

Citations

– 1. Si H, Wang J, He R, et al. Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor. Frontiers in oncology. 2021, 11: 807200-807200. 2. Luschnig P, Kienzl M, Roula D, et al. The JAK1/2 inhibitor baricitinib suppresses eosinophil effector function and restricts allergen-induced airway eosinophilia. Biochemical Pharmacology. 2021: 114690. 3. Ouyang P, Tao Y, Wei W, et al.Spring Viremia of Carp Virus Infection Induces Carp IL-10 Expression, Both In Vitro and In Vivo.Microorganisms.2023, 11(11): 2812. 4. Development and evaluation of two whole-blood flow cytometry protocols for monitoring patients treated with JAK inhibitors

References

– Changelian PS, et al, Science, 2003, 302(5646), 875-878.

CAS Number

– 477600-75-2

Molecular Weight

– C16H20N6O

Compound Purity

– 0.9974

SMILES

– C[C@@H]1CCN(C[C@@H]1N(C)C1=C2C=CNC2=NC=N1)C(=O)CC#N

Pathway

– Chromatin/Epigenetic|||Angiogenesis|||Apoptosis|||Stem Cells|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.