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Tin protoporphyrin IX dichloride
$130 – $210
Products Details
Product Description
– Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].
Web ID
– HY-101194
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C34H32Cl2N4O4Sn
References
– [1]Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.
CAS Number
– 14325-05-4
Molecular Weight
– 750.26
Compound Purity
– 95.0
SMILES
– [Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5)[Cl-]
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 0.1 M NaOH : 14.29 mg/mL (ultrasonic;adjust pH to 12 with NaOH)|1M NaOH : 5 mg/mL (ultrasonic)|DMF : 1 mg/mL (ultrasonic;warming)|DMSO : 0.5 mg/mL (ultrasonic;warming)
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
