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TH588
$72 – $528
Products Details
Product Description
– TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
Web ID
– HY-12814
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H12Cl2N4
References
– [1]Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
CAS Number
– 1609960-31-7
Molecular Weight
– 295.17
Compound Purity
– 99.20
SMILES
– NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 16 mg/mL (ultrasonic;warming)
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
