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Products Details
Product Description
– TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].
Web ID
– HY-146243
Shipping
– Room temperature
Molecular Formula
– C30H38N6O
References
– [1]Mao Z, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.
CAS Number
– 2766209-50-9
Molecular Weight
– 498.66
SMILES
– CN(CCC1)[C@@H]1COC2=NC(N3C[C@H]4N[C@H](CC4)C3)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Ras
Isoform
– K-Ras
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
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