Download Files:

TCIP 1

SKU T79801-25 mg Category Small Compound Brand: TargetMol

Price range: 9,688 CAD through 17,208 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

100 mg 25 mg 50 mg

Clear

Products Details

Product Description

– TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expression by directing endogenous cancer drivers or transcription factors to the promoters of these genes. Additionally, TCIP 1 exhibits a gain-of-function mechanism, displaying both cell and tissue specificity, and it establishes a ternary complex with BCL6 and BRD4. It counteracts BCL6’s inhibitory effect on apoptosis gene expression, leading to the activation of apoptosis. Furthermore, TCIP 1 markedly suppresses MYC oncogene expression and curtails the proliferation of diffuse large B-cell lymphoma (DLBCL) [1].

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T79801

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C50H58Cl2N12O6S

References

– Gourisankar S, Krokhotin A, Ji W, et al. Rewiring cancer drivers to activate apoptosis. Nature. 2023;620(7973):417-425.

Molecular Weight

– C50H58Cl2N12O6S

SMILES

– CNC(COC1=CC2=C(C(OC)=CC(NC3=NC(N4CCC(C(NCCCCCCCNC(C[C@@H]5N=C(C6=CC=C(Cl)C=C6)C7=C(SC(C)=C7C)N8C(C)=NN=C58)=O)=O)CC4)=NC=C3)=C2)N(C)C1=O)=O

Pathway

– Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.