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Succinyl phosphonate (trisodium salt)
$420 – $600
Products Details
Product Description
– Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].
Web ID
– HY-12688A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C4H4Na3O6P
Citations
– Research Square Preprint. 2022.|Research Square Print. 2022 May.|ACS Chem Biol. 2020 Aug 21;15(8):2041-2047.|Cancer Res. 2019 Jul 1;79(13):3281-3293. |Cell Death Dis. 2021 Oct 25;12(11):999.|Exp Cell Res. 2019 Sep 15;382(2):111483. |Free Radic Biol Med. 2016 Apr 9;96:22-33. |Plant Signal Behav. 2019;14(7):1604015.|Planta. 2018 Oct;248(4):963-979.|Redox Biol. 2023 Jun.
References
– [1]Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70.|[2]Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21.|[3]Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6.|[4]Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.
CAS Number
– 864167-45-3
Molecular Weight
– 248.01
Compound Purity
– 98.0
SMILES
– O=C(O[Na])CCC(P(O[Na])(O[Na])=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Neurological Disease
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
