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Sinomenine hydrochloride
$25 – $28
Products Details
Product Description
– Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].
Web ID
– HY-15122A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H24ClNO4
Citations
– bioRxiv. 2023 Jun 3.|Free Radic Biol Med. 2018 Jun 2;124:205-213.|Acta Pharm Sin B. 2021 Nov;11(11):3465-3480.|Chem Biol Drug Des. 2022 Oct 27.|Exp Ther Med. 2021 Apr 18.|J Inflamm Res. 2023 Oct 20:16:4777-4791.|Phytother Res. 2023 Apr 10.
References
– [1]Wang MH, et al. Activation of opioid mu-receptor by sinomenine in cell and mice.Neurosci Lett. 2008 Oct 10;443(3):209-12.|[2]Song L, et al. Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res Commun. 2015 Aug 28;464(3):705-10.|[3]Gao T, et al. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol. 2013 Dec 5;721(1-3):5-11.|[4]Zhu Q, et al. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci Rep. 2014 Dec 1;4:7270.
CAS Number
– 6080-33-7
Molecular Weight
– 365.85
Compound Purity
– 98.67
SMILES
– OC(C1=C2C[C@@]3([H])[C@](C=C4OC)([H])[C@@]1(CCN3C)CC4=O)=C(C=C2)OC.Cl
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming)|H2O : 16.67 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;NF-κB;Opioid Receptor
Isoform
– NF-κB;μ Opioid Receptor/MOR
Pathway
– Apoptosis;Autophagy;GPCR/G Protein;Neuronal Signaling;NF-κB
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
