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Selitrectinib

SKU T7435-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 54 CAD through 754 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T7435

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H21FN6O

Citations

– 1. Qin Q, Fu Q, Wang X, et al.Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors.European Journal of Medicinal Chemistry.2023: 115291. 2. Qin Q, Guo Z, Lu S, et al.Discovery of novel 3-(1H-pyrazol-4-yl)-1H-indazole derivatives as potent type II TRK inhibitors against acquired resistance.European Journal of Medicinal Chemistry.2023: 115953. 3. Qin Q, Lu S, Guo Z, et al.Discovery of novel indazole derivatives as second-generation TRK inhibitors.European Journal of Medicinal Chemistry.2024: 116640.

References

– Drilon A , Nagasubramanian R , Blake J F , et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors[J]. Cancer Discovery, 2017, 7(9):CD-17-0507.

CAS Number

– 2097002-61-2

Molecular Weight

– C20H21FN6O

Compound Purity

– 0.9955

SMILES

– [H][C@]12CCCN1c1ccn3ncc(C(=O)N[C@H](C)CCc4ncc(F)cc24)c3n1

Pathway

– Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.