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Selisistat

SKU T6111-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 69 CAD through 952 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50 = 38 nM) and can be utilized in the study of neurological disorders such as Huntington’s chorea.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6111

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H13ClN2O

Citations

– 1. Yuan J, Wei Z, Xin G, et al. Vitamin B12 Attenuates Acute Pancreatitis by Suppressing Oxidative Stress and Improving Mitochondria Dysfunction via CBS/SIRT1 Pathway. Oxidative Medicine and Cellular Longevity. 2021, 2021. 2. Lu S, Zhou J, Yang C, et al. γ-glutamylcysteine ameliorates D-gal-induced senescence in PC12 cells and mice via activating AMPK and SIRT1. Food & Function. 2022 3. Luo Y, Lu S, Gao Y, et al. Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy. Aging (Albany NY). 2020, 12(2): 1704. 4. Luo Y, Lu S, Gao Y, et al. Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy. Aging (Albany NY). 2020, 12(2): 1704. 5. Chen W, Lin B, Xie S, et al. Naringenin protects RPE cells from NaIO3-induced oxidative damage in vivo and in vitro through up-regulation of SIRT1. Phytomedicine. 2020: 153375 6. Zhou J, Yan X, Bi X, et al.γ-Glutamylcysteine rescues mice from TNBS-driven inflammatory bowel disease through regulating macrophages polarization.Inflammation Research.2023: 1-19. 7. Cao P, Wang Y, Zhang C, et al.Quercetin ameliorates non-alcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy.The Journal of Nutritional Biochemistry.2023: 109414. 8. Peng X, Yuan H, Chen G, et al.Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway.Cellular and Molecular Biology.2023, 69(13): 96-101. 9. Wang L, Hou J, Xu H, et al.Angong Niuhuang Pill pretreatment alleviates cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through the SIRT1-H4K16ac axis.Journal of Ethnopharmacology.2024: 119214.

References

– Kabra N, et al. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem. 2009 Jul 3;284(27):18210-7.

CAS Number

– 49843-98-3

Molecular Weight

– C13H13ClN2O

Compound Purity

– 0.9994

SMILES

– NC(=O)C1CCCC2=C1NC1=CC=C(Cl)C=C21

Pathway

– Chromatin/Epigenetic|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.