Download Files:
Selisistat
$55 – $300
Products Details
Product Description
– Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington’s disease[1][2].
Web ID
– HY-15452
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H13ClN2O
References
– [1]Smith MR, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington’s disease. Hum Mol Genet. 2014;23(11):2995-3007.|[2]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 [published correction appears in J Med Chem. 2007 Mar 8;50(5):1086]. J Med Chem. 2005;48(25):8045-8054.
CAS Number
– 49843-98-3
Molecular Weight
– 248.71
Compound Purity
– 99.89
SMILES
– O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Clinical Information
– Phase 2
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Sirtuin
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
