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SB225002

SKU T1955-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 69 CAD through 1,579 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1955

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H10BrN3O4

Citations

– 1. Ji X, Sun T, Xie S, et al. Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway. Cell Death Discovery. 2021, 7(1): 1-11. 2. Wang W, Zhang M, Huang Z, et al. Knockdown of CXCL5 inhibits the invasion, metastasis and stemness of bladder cancer lung metastatic cells by downregulating CD44. Anti-Cancer Drugs. 2022, 33(1): e103-e112. 3. Wang W, Zhang M, Huang Z, et al. Knockdown of CXCL5 inhibits the invasion, metastasis and stemness of bladder cancer lung metastatic cells by downregulating CD44. Anti-Cancer Drugs. 2022, 33(1): e103-e112. 4. Ju C, Yuan F, Wang L, et al.Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway.Neurobiology of Disease.2023: 105988. 5. Jiang S, Li W, Song M, et al.CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration.Molecular Immunology.2024, 169: 50-65. 6. Wang Y, Ding W, Hao W, et al.CXCL3/TGF-β-Mediated Crosstalk Between CAFs and Tumor Cells Augments RCC Progression and Sunitinib Resistance.iScience.2024 7. Chen K, Ye Q, Zhang Y, et al.CXCL1-CXCR2 signaling mediates the activation of microglia in the nucleus tractus solitarii to promote pancreatic cancer-induced pain.Brain, Behavior, and Immunity.2024

References

– White JR, et al. J Biol Chem. 1998, 273(17), 120095-120098.

CAS Number

– 182498-32-4

Molecular Weight

– C13H10BrN3O4

Compound Purity

– 0.9985

SMILES

– N(C(NC1=C(Br)C=CC=C1)=O)C2=C(O)C=C(N(=O)=O)C=C2

Target

– Others

Pathway

– Autophagy|||GPCR/G Protein|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.