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Products Details
Product Description
– SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1].
Web ID
– HY-15106
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C28H36N2O4
References
– [1]Kumar S, et al. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation. Bone. 2010 Feb;46(2):534-42.
CAS Number
– 351490-26-1
Molecular Weight
– 464.60
SMILES
– O=C(OCC)CCC1=CC=C(C#N)C(OC[C@H](O)CNC(C)(C)CC2CC3=C(C=CC=C3)C2)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CaSR
Pathway
– GPCR/G Protein
Product type
– Reference compound
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