– 1. Sauchinone is a useful adjunctive [research relevance to related conditions]. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative stress in vivo and in vitro. 3. Sauchinone diminishes LPS-induced neutrophil activation and acute lung injury. 4. Sauchinone-induced HO-1 expression plays a key role in the vascular protective effects of Sauchinone in HUVEC. 5. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes.