Download Files:

S63845

SKU T5346-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 126 CAD through 1,045 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 25 mg 5 mg 50 mg

Clear

Products Details

Product Description

– S63845 is a selective myeloid leukemia 1(MCL1) inhibitor that binds to human MCL1 with a Kd of 0.19 nM.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T5346

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C39H37ClF4N6O6S

Citations

– 1. Li Y, Lee H H, Jiang V C, et al.Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins.Cell Death & Disease.2023, 14(11): 714.

References

– András Kotschy, Zoltán Szlavik, James Murray.The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.Nature. 2016 Oct 27;538(7626):477-482.

CAS Number

– 1799633-27-4

Molecular Weight

– C39H37ClF4N6O6S

Compound Purity

– 0.9856

SMILES

– CN1CCN(CCOc2ccc(-c3c(sc4ncnc(O[C@@H](Cc5ccccc5OCc5ccnn5CC(F)(F)F)C(O)=O)c34)-c3ccc(F)o3)c(C)c2Cl)CC1

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.