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Products Details
Product Description
– (S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 (example 39) is a PERK inhibitor, with an IC50 of 0.101-0.250 μM[1][2].
Web ID
– HY-145835A
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C25H26F2N4O3
References
– [1]Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.|[2]Alan C. Rigby, et al. Perk inhibitors for treating viral infections. WO2021231782A1.
CAS Number
– 2616821-92-0
Molecular Weight
– 468.50
SMILES
– O=C(C1=CC(C2=CC=C(NC([C@H](C3=CC(F)=CC(F)=C3)O)=O)C=C2CC)=CN=C1N)NC(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– PERK
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
